Adam Sperling, MD, PhD Follow
Physician scientist @BrighamHeme and @DFCI. Former @BrighamMedRes. Heme malignancy. Clonal hematopoiesis. Multiple myeloma. Live in Boston but root for LA.
Janssen Announces Unblinding of Phase 3 CARTITUDE-4 Study of CARVYKTI® (cilta-cel) as Primary Endpoint Met in Treatment of Patients with Relapsed and Refractory Multiple Myeloma #mmsm #cellulartherapy #CARTsm https://www.prnewswire.com/news-releases/janssen-announces-unblinding-of-phase-3-cartitude-4-study-of-carvykti-cilta-cel-as-primary-endpoint-met-in-treatment-of-patients-with-relapsed-and-refractory-multiple-myeloma-301732398.html
Out in @CircAHA today, we use high quality #CHIP calls to show that IL6 receptor signaling modulates association between CHIP and CVD in 'full' UK Biobank dataset. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062126 https://twitter.com/DrFlashHeart/status/1617607601201774592
Last week, I shared how we derived CHIP calls in the UK Biobank (N ~450k).
In a study out today in Circulation (@CircAHA), we use these CHIP calls to contribute to an ongoing debate regarding IL-6 signaling mediating the association between CHIP & CAD.
An inspiration for the new year! Dr. Alex Herrera was on the @cityofhope "Expanding Hope" float in the #roseparade2023 . The mother of one of his patients walked alongside the float for 2.5 miles throwing him kisses to give him thanks and gratitude. http://bit.ly/3vQX2Do
Oh my. So sad to hear.
It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.
Excited that our efforts, led by @tal_sella and @AnnPartridgeMD, to study patients’ perspectives on testing for #CHIP is now published @BloodAdvances https://ashpublications.org/bloodadvances/article/6/24/6151/486674/Patient-perspectives-on-testing-for-clonal