Excited to share our paper in @NatureBiotech. We've developed a CAR-Enhancer (CAR-E) that enhances the activity and persistence of CAR T-cells. These memory CAR T-cells can re-expand months later. Here's a brief summary:
Endogenous polymerization of BTB domains: Our initial hypothesis was that this would lead to protein degradation, but instead, polymerization led to enhanced chromatin binding at homotypic clusters, causing transcriptional repression. Great story spearheaded by amazing Park Team!